At the time of her death, Jennifer was working as a record company executive in Los Angeles. She died April 2 2001 at 6:20am, after her Jeep Cherokee crashed into a row of parked cars in Los Angeles. She had just come from Marilyn Manson's mansion, where she was apparently getting high. Marilyn Manson, who was featured in "Lost Highway" and also agreed to make cameo appearances in the MD TV series, was claimed responsible for her death when having been negligent in "instructing the woman to operate a motor vehicle in her incapacitated condition". Jennifer Syme was buried at Westwood Memorial Park next to her daughter. In tribute to his former assistant David Lynch dedicates Mulholland Dr. (2001) to her in the closing credits of the film.
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